Controlled Release Imatinib Mesylate Tablet Formulation: Using Hydrophilic Matrix System

Formulation of Controlled Release Pelubiprofen Tablet Using Matrix-Forming Polymers

Formulation and In Vitro, In Vivo Evaluation of Effervescent Floating Sustained-Release Imatinib Mesylate Tablet

INTRODUCTION Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent administration to keep the plasma drug level at an effective range. This might cause side effects, reduced effectiveness and poor thera...

Formulation and Evaluation of Sustained Release Metoprolol Succinate Tablet using Hydrophilic gums as Release modifiers

The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol succinate using natural hydrophilic gums such as karaya gum and xanthan gum as a release modifier. Nine batches were prepared by using karaya gum (KG) and xanthan gum (XG) in concentration of 15%, 20% and 25% alone and in combination of 2:8. Matrix tablets were prepared by wet granulation m...

Formulation of Controlled Release Matrix Tablet of Diclofenac Sodium Using Cross Linked Starch Urea

The présent works aims to develop controlled release matrix tablet of diclofenac sodium with modified starch cross linked starch urea as an sustained release polymer and to evaluate the prepared dosage form for physical parameters like weight variation, hardness, friability and drug content. Cross linked starch urea is modified starch introducing desirable alterations in the starch structure so...

Formulation, Evaluation and Optimization of Sustained Release Tablets of Indapamide using Hydrophilic Matrix system

Different formulations of Indapamide 1.5mg sustained release tablets were formulated using wet granulation method using hydrophilic polymer. The tablets were subjected to physicochemical studies, in vitro release studies, kinetic modeling and stability studies to find out the best formulation. The in vitro release studies were conducted for 16 hours using USP 30 apparatus type I (Basket method)...